Study on the Effect of Phaseolus vulgaris Methanol Extract on Haloperidol and Tacrine Induced Parkinsonism

Abstract: Background: Parkinson’s disease is neurodegenerative with no cure till now, there are treatments that can be explored to ease the symptoms of this disease, and using plant extract we explore possibility neutralizing adverse providing better quality life patients. Purpose: To demonstrate Anti-parkinson’s activity Phaseolus vulgaris methanol pod by behavioural models in Wister Albino rats. Materials Methods: Animals were given (PVME) prior Haloperidol Tacrine induced Parkinsonism. Results: vulgaris, family (Leguminosae) a plant, well known for its Traditional Ayurvedic application treatment various diseases. In present studies, pods used evaluate Antiparkinson’s behavioral The here Haloperidol-induced catalepsy Tacrine-induced vacuous jaw movement. 200 400 mg/kg rats inducing Catalepsy. Haloperidol, an Antipsychotic drug induces motor like PVME administration 5 days, on last day (1mg/kg i.p) was observed, it seen reduces score dose-dependent manner. Behavioral parameters also observed Tacrine, which Anticholesterase chewing movements orofacial bursts. results noted duration 1 hr found dose significantly bursts as compared dose. close standard group (levodopa + carbidopa). Conclusion: study conducted demonstrates Neuroprotective effectiveness assess disease. effect shown treat dysfunction attributed tendency reduce oxidative stress having phenolic content. Keywords: Levodopa, Neuroprotective, Carbidopa, Oxidative stress.